Application of Thermodynamic Phase Diagrams and Gibbs Free Energy of Mixing for Screening of Polymers for Their Use in Amorphous Solid Dispersion Formulation of a Non-Glass-Forming Drug

The objective of the present investigations was to assess use thermodynamic phase diagrams and Gibbs free energy mixing, ?Gmix, for screening polymeric carriers by determining ideal drug-loading an amorphous solid dispersion formulation optimum processing temperature hot-melt extrusion a non-glass-forming drug. Mefenamic acid (MFA) used as model drug four chemically distinct polymers with close values solubility parameters, viz. Kollidon® VA64, Soluplus®, Pluronic® F68, Eudragit® EPO, were carriers. constructed using melting point depression data, Flory-Huggins theory, Gordan-Taylor equation. mixing estimated drug-polymer interaction parameter, ?, theory. rank order miscibility MFA in based on difference their ??, did not correlate well plots. study highlights limitation parameter method poorly glass-forming drugs reiterates applicability plots extrusion.